Blood Type Compatibility & Inheritance Checker
Check blood transfusion compatibility for red blood cells and plasma. Includes Mendelian parental inheritance calculator, Punnett squares.
Patient / Recipient Blood Type
Transfusion Compatibility Matrix
All 8 donor types evaluated for this recipient:
⚖️ Decision Verdict: Compatible Transfusion
Patient with blood type O+ can safely receive Red Blood Cells from O- and O+ donors without hemolytic transfusion reactions.
Hematology Profile & Clinical Insights
About this tool
How to use it
- Select your desired mode: Transfusion Compatibility (Donor/Recipient) or Parental Inheritance (Child Blood Type).
- For Transfusions: Select the patient's blood type and potential donor's blood type, toggle between Red Blood Cells and Plasma.
- For Inheritance: Select biological parent 1 (mother) and parent 2 (father) blood types.
- Inspect the interactive 8-badge compatibility matrix to view which blood types are compatible or genetically feasible.
- Review donor pool percentages, antigen/antibody immunogenicity, and Rh-incompatibility pregnancy advice.
Why it matters
ABO and Rhesus blood group compatibility is vital in emergency medicine and obstetrics. Transfusing incompatible red blood cells triggers acute hemolytic transfusion reaction (AHTR), causing intravascular lysis and renal shutdown. Furthermore, expectant mothers need to identify Rh(D) incompatibility to prevent hemolytic disease of the fetus and newborn (HDFN).
When to use it
Use this checker when preparing for blood donation, checking family genetics, or understanding hospital blood compatibility test reports.
Good to know
Medical Notice: In clinical settings, blood compatibility requires laboratory crossmatching and antibody screening beyond ABO/Rh typing to detect minor atypical red cell antibodies (Kell, Duffy, Kidd).
Common questions
Why is O Negative called the universal red blood cell donor?
Type O- red blood cells lack A, B, and Rh surface antigens. Because there are no major antigens for a recipient's antibodies to target, O- blood can be safely given in acute emergencies when a patient's blood type is unknown.
Why is AB Positive the universal red blood cell recipient?
AB+ individuals possess A, B, and Rh antigens on their red blood cells, meaning their immune system does not form antibodies against A, B, or Rh proteins. They can safely receive red blood cells of any blood type.
Why are plasma compatibility rules reversed?
While red blood cells carry antigens, blood plasma carries antibodies. AB individuals have zero antibodies in their plasma, making AB plasma universal for all recipients. Conversely, Type O plasma contains anti-A and anti-B antibodies and can only be given to Type O recipients.
Can two O-type parents have an A or B child?
Under classical Mendelian genetics, two biological parents with Type O blood can only pass the recessive 'i' allele and can only have children with Type O blood. Exceptionally rare exceptions occur with the Bombay phenotype (lack of H antigen).
What is Rh incompatibility in pregnancy?
If an Rh-negative mother carries an Rh-positive fetus, fetal red blood cells entering maternal circulation can trigger anti-D antibody production. Administering prophylactic Rho(D) immune globulin (RhoGAM) at 28 weeks and post-delivery prevents this sensitization.